Hal Blumenfeld Laboratory

Yale University Department of Neurology
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Publications
 
Textbooks:
 
 
Journal Articles:

Blumenfeld H, Lampert A, Klein JP, Mission J, Chen MC, Rivera M, Dib-Hajj S, Brennan AR,

Hains BC, Waxman SG. (2009).   Role of hippocampal sodium channel Nav1.6 in kindling

epileptogenesis.  Epilepsia, 50(1): 44-55.

 

Sanganahalli BG, Herman P, Blumenfeld H, Hyder F.  (2009).  Oxidative Neuroenergetics in

Event-Related Paradigms.  Journal of Neuroscience, 29(6):1707-1718.

 

Herman P, Sanganahalli BG, Blumenfeld H, Hyder F.  (2009).  Cerebral oxygen demand for

short-lived and steady-state events.  J Neurochem, 109(s1): 73-79.

 

Blumenfeld H, Varghese G, Purcaro MJ, Motelow JE, Enev M, McNally KA, Levin AR, Hirsch

L.J., Tikofsky R, Zubal IG, Paige AL, Spencer SS.  (2009).  Cortical and subcortical networks

in human secondarily generalized tonic-clonic seizures.  Brain, 132(4): 999-1012.

 

Ellens DJ, Hong E, Giblin K, Singleton MJ, Bashyal C, Englot DJ, Mishra AM, Blumenfeld H. 

(2009).  Development of spike-wave seizures in C3H/HeJ mice. Epilepsy Research, 85(1) 53-

59.

 

Varghese G, Purcaro MJ, Motelow JE, Enev M, McNally KA, Levin AR, Hirsch L, Tikofsky R,

Paige AL, Zubal IG, Spencer SS, Blumenfeld H.  (2009).  Clinical use of ictal SPECT in

secondarily generalized tonic-clonic seizures.  Brain, 132(8): 2102-2113.

 

Heida JG, Englot DJ, Sacktor TC, Blumenfeld H, Moshé SL.  (2009).  Separating kindling and

LTP: Lessons from studies of PKMzeta in developing and adult rats.  Neurosci Lett, 453(3):

229-32.

 

Chahboune H, Mishra AM, DeSalvo MN, Staib LH, Purcaro M, Scheinost D, Papademetris X,

Fyson SJ, Lorincz ML, Crunelli V, Hyder F, Blumenfeld H.  (2009).  DTI abnormalities in

anterior corpus callosum of rats with spike-wave epilepsy.  Neuroimage, 47: 459-466.

[NIHMSID #115314].

Buch K, Blumenfeld H, Spencer S, Novotny E, Zubal IG.  (2008).  Evaluating the accuracy of

perfusion/metabolism (SPET/PET) ratio in seizure localization.  Eur J Nucl Med Mol

Imaging, 35(3):579-88.


Schridde U, Khubchandani M, Motelow JE, Sanganahalli BG, Hyder F, Blumenfeld H.  (2008). 

Negative BOLD with large increases in neuronal activity.  Cerebral Cortex, 18:1814–1827.


Blumenfeld H, Klein JP, Schridde U, Vestal M, Rice T, Khera DS, Bashyal C, Giblin K, Paul-

Laughinghouse C, Wang F, Phadke A, Mission J, Agarwal RK, Englot DJ, Motelow J,

Nersesyan H, Waxman SG, Levin AR.  (2008).  Early treatment suppresses the development

of spike-wave epilepsy in a rat model.  Epilepsia, 49(3):400–409.


Englot DJ, Mishra AM, Mansuripur PK, Herman P, Hyder F, Blumenfeld H.  (2008).  Remote

effects of focal hippocampal seizures on the rat neocortex.  Journal of Neuroscience,

28(36):9066 –9081.

Maandag NJG, Coman D, Sanganahalli BG, Herman P, Smith AJ, Blumenfeld H, Shulman RG,

Hyder F.  (2007).  Energetics of neuronal signaling and fMRI activity.  Proc Natl Acad Sci, USA,104(51):20546-20551.

 
Blumenfeld H, Rivera M, Vasquez JG, Shah A, Ismail D, Enev M, Zaveri HP. (2007). Neocortical and thalamic spread of amygdala kindled seizures. Epilepsia 48(2): 254-62.
 
Enev M, McNally KA, Varghese G, Zubal IG, Ostroff RB, Blumenfeld H. (2007). Imaging onset and propagation of ECT-induced seizures. Epilepsia, 48(2): 238-44.

Blumenfeld H (2005). Cellular and network mechanisms of spike-wave seizures. Epilepsia, 46(Sup 9):21–33.

Kida I, Smith AJ, Blumenfeld H, Behar KL, Hyder F (2006). Lamotrigine suppresses neurophysiological responses to somatosensory stimulation in the rodent. Neuroimage, 29: 216-224.
 
Blumenfeld H (2005). Consciousness and epilepsy: Why are patients with absence seizures absent? Prog Brain Res, 150: 271-286.
 
McNally KA, Paige AL, Varghese G, Zhang H, Novotny EJ, Spencer SS, Zubal IG, Blumenfeld H. (2005). Localizing Value of Ictal-Interictal SPECT Analyzed by SPM (ISAS). Epilepsia, 46(9): 1450 –1464.
 
Blumenfeld H, Rivera M, McNally KA, Davis K, Spencer DD, Spencer SS. (2004). Ictal neocortical slowing in temporal lobe epilepsy. Neurology, 63: 1015-1021.
 
Nersesyan H, Herman P, Erdogan E, Hyder F, Blumenfeld H. (2004). Relative changes in cerebral blood flow and neuronal activity in local microdomains during generalized seizures. J Cereb Blood Flow Metab, 24(9): 1057-1068.
 
Nersesyan H, Hyder F, Rothman D, Blumenfeld H. (2004). Dynamic fMRI and EEG recordings during spike-wave seizures and generalized tonic-clonic seizures in WAG/Rij rats. J Cereb Blood Flow Metab, 24(6): 589-599.
 
Blumenfeld H, McNally KA, Vanderhill SD, Paige AL, Chung R, Davis K, Norden AD, Stokking R, Studholme C, Novotny EJ, Zubal IG, Spencer SS. (2004). Positive and negative network correlations in temporal lobe epilepsy. Cerebral Cortex, 14(8): 892-902.
 
Hyder F, Blumenfeld H. (2004). Relationship between CMRO2 and neuronal activity. In: Brain Energetics and Neuronal Activity: Applications to fMRI and Medicine. RG Shulman, DL Rothman (Eds). John Wiley & Sons, Inc. New York, 173-194.
 
Klein JP, Khera DS, Nersesyan H, Kimichi EY, Waxman SG, Blumenfeld H. (2004). Dysregulation of sodium channel expression in cortical neurons in a rodent model of absence epilepsy. Brain Res, 1000: 102 109.
 
McNally KA, Blumenfeld H. (2004). Focal network involvement in generalized seizures: New insights from ECT. Epilepsy and Behavior, 5: 3-12.
 
Blumenfeld, H., Taylor J. (2003). Why do seizures cause loss of consciousness? The Neuroscientist, 9(5) 301-310.
 
Blumenfeld, H., McNally, K.A., Ostroff, R., Zubal, I.G. (2003). Targeted prefrontal cortical activation with bifrontal ECT. Psychiatry Res: Neuroimaging. 123 (3): 165-170.
 
Blumenfeld, H., Westerveld, M., Ostroff, R.B., Vanderhill, S.D., Freeman, J., Necochea, A., Uranga, P., Tanhehco, T., Smith, A., Seibyl, J.P., Stokking, R., Studholme, C., Spencer, S.S., Zubal, I.G. (2003). Selective frontal, parietal and temporal networks in generalized seizures. Neuroimage, 19: 1556-1566.
 
Blumenfeld, H. (2003). From Molecules to Networks: Cortical/Subcortical Interactions in the Pathophysiology of Idiopathic Generalized Epilepsy. Epilepsia. 44(Suppl. 2): 7-15.
 
Weisman D, Hisama FM, Waxman SG, Blumenfeld H. (2003). Going deep to cut the link: Cortical disconnection syndrome caused by a thalamic lesion. Neurology. 60 (11): 1865-66.
 
Hyder F, Kida I, Smith AJ, Blumenfeld H, Shulman RG, Rothman DL. (2002). Quantitative fMRI of rat brain by multi-modal MRI and MRS measurements. International Symposium on Brain Activation and CBF Control (Minoru Tomita Ed.). International Congress Series, 1235: 57-71.
 
Smith AJ, Blumenfeld H, Behar KL, Rothman DL, Shulman RG, Hyder F. (2002). Cerebral energetics and spiking frequency: The neurophysiological basis of fMRI. Proc Natl Acad Sci, USA. 99(16):10765-10770.
 
Zaatreh MM, Spencer DD, Thompson JL, Blumenfeld H, Novotny EJ, Mattson RH, Spencer SS. (2002). Frontal lobe tumoral epilepsy: Clinical, neurophysiological features and predictors of surgical outcome. Epilepsia. 43(7): 727-733.
 
Norden A, Blumenfeld H. (2002). The Role of Subcortical Structures in Human Epilepsy. Epilepsy and Behavior. 3: 219-231.
 
Blumenfeld, H. (2002). The thalamus and seizures. Archives of Neurology, 59: 135-137.
Chang, D., Zubal, I.G., Gottschalk, C., Necochea, A., Stokking, R., Studholme, C., Corsi, M., Slawski, J. Spencer, S.S., and
 
Blumenfeld, H. (2002). Comparison of Statistical Parametric Mapping and SPECT Difference Imaging in Patients with Temporal Lobe Epilepsy. Epilepsia, 43(1): 68-74.
 
Blumenfeld, H., and McCormick, D.A. (2000). Corticothalamic inputs control the pattern of activity generated in thalamocortical networks. J. Neurosci. 20(13): 5153-5162.
 
Eliot, L.S., Kandel, E.R., Siegelbaum, S.A. and Blumenfeld, H. (1993). Imaging terminals of Aplysia sensory neurons demonstrates role of enhanced Ca2+ influx in presynaptic facilitation. Nature 361, 634-637.
 
Blumenfeld, H., Zablow, L., Sabatini, B. (1992). Evaluation of cellular mechanisms for modulation of calcium transients using a mathematical model of fura-2 Ca2+ imaging in Aplysia sensory neurons. Biophysical J. 63, 1146-1164.
 
Blumenfeld, H., Spira, M.E., Kandel, E.R. and Siegelbaum, S.A. (1990). Facilitatory and inhibitory transmitters modulate calcium influx during action potentials in Aplysia sensory neurons. Neuron 5, 487-499.